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Get Steven Byrnes on Dwarkesh Podcast

Artificial IntelligenceBiotechnologyBrain-Like AGITechnical AI Alignment+1
SB
Dwarkesh Podcast
16
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Nomination created on December 3, 2025

dlogos.xyz>Dwarkesh Podcast>

Get Steven Byrnes on Dwarkesh Podcast!

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The Case for This Conversation

SB
Guest
Steven Byrnes

Researching Artificial General Intelligence Safety, via thinking about neuroscience and algorithms. @AsteraInstitute. For substack etc see https://t.co/p5G9VoQEdX

Dwarkesh Podcast
Podcast
Dwarkesh Podcast

Dive into the cutting-edge worlds of technology and science with Dwarkesh Patel's meticulously researched interviews that bring together brilliant minds to unpack revolutionary ideas in AI, biotech, and beyond. Each episode delivers profound, thought-provoking conversations that challenge conventional wisdom and illuminate the paths shaping humanity's future.

Steven Byrnes is one of the clearest voices on brain‑like AGI safety right now, and in his December 11, 2025 year‑in‑review he laid out concrete 2026 plans to push “reward function design” from blog posts into usable guidance for labs, exactly the kind of work the field needs as models get more agentic. Today, with policymakers and researchers shifting from AI hype to hard evaluation, having Byrnes explain his latest thinking on Dwarkesh’s deeply researched show would help decision‑makers grasp why mis‑specified rewards can turn tomorrow’s powerful systems into real risks, and what to do about it.

He is actively publishing and debating these ideas on the Alignment Forum, and he just came off recent public conversations about brain‑like AGI at leading venues. That momentum makes his appearance timely for translating cutting‑edge safety research into practical frameworks the audience can act on now.

Byrnes has not been on the Dwarkesh Podcast before, and the show has repeatedly referenced his work without hosting him, so this would be a first and overdue conversation.

If you want rigorous, usable safety insights in front of the people who can act on them, support this nomination today.

Sources

alignmentforum.orgalignmentforum.org
RH
The Joe Rogan Experience

Richard Heart

on The Joe Rogan Experience

97votes
AB
Anna Buh voted 13d ago
Vote for Richard
DA
All-In with Chamath, Jason, Sacks & Friedberg

Dario Amodei

on All-In with Chamath, Jason, Sacks & Friedberg

68votes
TJ
Timothy John voted 8d ago
RH
The Tucker Carlson Show

Richard Heart

on The Tucker Carlson Show

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Vote for Richard
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Candace

Andrew Wilson

on Candace

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Revenge of the Cis – More Like Radio

Revenge of the Cis

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Revenge of the Cis – More Like Radio

Grok

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    What People Are Saying

    Voices already speaking out in support of this conversation.
    Adam Marblestone
    Adam Marblestone
    @AdamMarblestone
    ·Follow
    Replying to @JoanneZPeng

    Your GOAT guest liked my 2016 view x.com/karpathy/statu… & Steve Byrnes has made that view actually make more sense, e.g., lesswrong.com/posts/GnmLRerq… I'd only spend 20% on what I'm now best known for (cheerleading @E11BIO) but could put no bounds on how much I'd shill Steve Byrnes

    Andrej Karpathy
    Andrej Karpathy
    @karpathy

    "Towards an integration of deep learning and neuroscience" biorxiv.org/content/biorxi… [pdf]; Good review article

    12:25 PM · Dec 5, 2025
    3
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    Read more on X
    BCurated by Brian Lowenstein 9 months ago
    Brian Lowenstein9 months ago
    Mathtician
    Mathtician
    @mathtician
    ·Follow

    Absolutely, I think he might actually be the one who takes us into the next era of neuroscience and psychology

    11:48 PM · Dec 4, 2025
    1
    Reply
    Read more on X
    BCurated by Brian Lowenstein 9 months ago
    Brian Lowenstein9 months ago
    Jonas Hallgren
    Jonas Hallgren
    @JonasTorvild
    ·Follow
    Replying to @dwarkesh_sp

    Please do Steven Byrnes! He's probably the person with the deepest neuroscience expertise I know of: lesswrong.com/s/HzcM2dkCq7fw… (Anecdotally: I asked him about a book on the evolution of mammalian memory systems once which was relatively obscure and he knew it completely)

    7:53 PM · Dec 4, 2025
    1
    Reply
    Read 1 reply
    BCurated by Brian Lowenstein 9 months ago
    Brian Lowenstein9 months ago
    Franz K
    Franz K
    @TrialByNitrogen
    ·Follow

    Steven Byrnes (has done multiple extensive series on this exact neuroscience / ML angle - "Intro to Brain Like AI safety" etc) @steve47285

    5:55 AM · Dec 5, 2025
    1
    Reply
    Read more on X
    BCurated by Brian Lowenstein 9 months ago
    Brian Lowenstein9 months ago

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