Get Sebastian Seung on Dwarkesh Podcast

Sebastian Seung matters right now because he co-led the April 2025 Nature papers that mapped roughly half a billion synaptic connections in mouse visual cortex, the most detailed wiring diagram of a mammalian brain region to date. That dataset is already fueling new research directions in neuroscience and machine learning, making his perspective uniquely valuable today.

At the same time, as President and Head of Samsung Research, Seung is helping steer Samsung’s 2026 push to embed AI across everything from phones and TVs to appliances, framed at CES 2026 as “Your Companion to AI Living.” He recently headlined a Samsung research forum with a keynote on brain‑inspired learning algorithms, putting him at the intersection of cutting‑edge science and products poised to reach hundreds of millions of users this year.

This conversation is urgent because the choices leaders like Seung make now will determine how on‑device AI handles privacy, reliability, and safety as it scales globally in 2026. As far as public episode listings show, Seung has not appeared on the Dwarkesh Podcast before, so this is a timely first chance to press him on how connectomics will shape consumer AI and robotics in the near term.

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