Next goal: 100
Nomination created on March 10, 2026
Get Dario Amodei on All-In with Chamath, Jason, Sacks & Friedberg!
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Anthropic CEO. https://t.co/qXHIf42RIT

Industry veterans, degenerate gamblers & besties Chamath Palihapitiya, Jason Calacanis, David Sacks & David Friedberg cover all things economic, tech, political, social & poker.
Dario Amodei is in the headlines this week as Anthropic’s reported revenue run rate jumps past $65 billion ahead of a potential IPO, signaling real competitive momentum in frontier AI. He has not been on All-In before, according to the show’s episode listings, so hearing him unfiltered here would be genuinely new for the audience.
At the same time, the AI safety fight is intensifying, with major labs throttling some releases and Anthropic publicly inviting “hard questions” about its models and policies. Amodei’s answers now could influence how quickly powerful systems roll out, who gets access, and what safeguards are adopted.
He is staking a nuanced position on open‑weight models, saying Anthropic has never backed a blanket ban and that smaller non‑dangerous models are a public good, while also warning that AI faces a crisis of public trust. That combination of hard numbers and hard choices is exactly what All-In’s operator and investor audience needs to interrogate today.
Back this booking so the Besties can press Amodei on near‑term model decisions like Anthropic’s recent Fable 5 redeploy and rumored updates, and help shape how AI gets built and governed right now. Support this nomination.
“With all the discussion around open weight models, I'd love to understand what Anthropic's long-term positioning will be for frontier models as intelligence gets more and more commoditized. All-in has definitely been critical at times to Dario's game with regulators so im sure this would be a worthwhile episode and great for the industry at large.”
“Would love to see Dario on All-In. There’s already so much overlap between the topics they discuss and the work he’s leading at Anthropic.”
“Jason has been calling for Dario to come on the show the past 12 episodes or so, and they've been covering Anthropic nonstop while disagreeing with many of Dario's stances. It would be an electric conversation”
1/2 Thanks Gavin for an especially thoughtful exchange. I don't usually spend much time on social media but I wanted to engage here because it really brings out the heart of an important conversation. First, on regulation, I think that “either concentrate it in the hands of a
Permission to treat: 1) @jason as a hostile moderator 2) @DavidSacks as a prosecutor 3) @friedberg as juror #1 4) @chamath just happy for another chance to talk his book even w/o getting close to saying "8090" or "factory" Should be fun!! ;-)
I don’t believe he is that brave! It’s would be GREAT but I don’t think he will do it!!!
Actually, that would be awesome, would tune in just for that. Meanwhile, his message / image / brand are still crippled. So sarcasm will continue until morale improves. x.com/dragosroua/sta…
If Anthropic released the iPhone
You should come on the pod next week, Dario; debating the nuances of the CAISI framework would be fascinating.
Dario should come on the pod!!! I've heard you guys talking about him for months. So I'm really looking forward to seeing the debate between @DavidSacks and @DarioAmodei
Brian has a great find here: Jacob Coxon, the kid who worked at Anthropic for a whopping two months before resigning, worked as a fellow for a Left-Wing political advocacy group in 2021.
The economic gains from AI will flow to capital far more than labor.
You've talked about AI's effect on jobs and this podcast has debated universal basic income. Dario, do current models point to a future where skills get commoditized faster than labor can retrain?
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Constitutional AI produces a helpful and harmless assistant, but some users find it too cautious or preachy. Are you satisfied with the character you've baked in?
BREAKING: ex-Anthropic Doomer Jacob Coxon tied to "Newspeak", British NGO involved with "hacking" democracy, Hillary Clinton, prison abolition, and extinction rebellion
AI safety is now a boardroom issue, not just a research issue.
As frontier models become embedded in enterprise workflows, AI risk conversations are shifting from academic alignment to institutional governance. Dario has been one of the most vocal champions of this shift — how does he see the dynamic playing out?