Get Siddhartha Mukherjee on Dwarkesh Podcast
Next goal: 5
The Case for This Conversation
Cancer physician, researcher. The Emperor of All Maladies: winner of Pulitzer Prize 2011. The GENE. Columbia Asst Professor. Stem cell biologist. New Yorker !
Dive into the cutting-edge worlds of technology and science with Dwarkesh Patel's meticulously researched interviews that bring together brilliant minds to unpack revolutionary ideas in AI, biotech, and beyond. Each episode delivers profound, thought-provoking conversations that challenge conventional wisdom and illuminate the paths shaping humanity's future.
Siddhartha Mukherjee matters today because he is actively shaping how AI meets oncology, co-founding Manas AI with Reid Hoffman in January 2025 to design new cancer drugs using Microsoft’s cloud and fresh venture funding. He has since argued that metabolism based co-therapies are the next frontier, laying out specific trial-ready ideas in a December 15, 2025 STAT essay that is already echoing through clinics and startups.
On the clinical side, his company Faeth Therapeutics moved from concept to data, launching a Phase 2 endometrial cancer trial in March 2025 and then reporting late-breaking ESMO 2025 results showing a 34 percent reduction in risk of progression with sapanisertib plus chemo. He is also updating the public conversation, from WBUR’s December 16, 2025 On Point on how our definition of cancer is changing to a new edition of The Emperor of All Maladies.
This is the perfect moment to put him in front of Dwarkesh’s AI heavy audience, where the stakes are immediate for drug discovery, biology, and policy. As far as public episode listings show, this would be his first appearance on the Dwarkesh Podcast, which makes the booking even more urgent and newsworthy, so please support this nomination today.
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Nomination created on January 16, 2026